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Gene Transcription and Regulation of Stem Cell Differentiation

Lead Physician: Jia Quan Wu, Ph.D.

This research combines stem cell biology and systems-based approaches involving genomics, proteomics, bioinformatics and functional assays to unravel gene transcription and regulatory mechanisms governing stem cell differentiation.

One major focus is investigating stem cell neural differentiation and developing effective and safe treatment for spinal cord injury and neurological diseases such as stroke.

The other area lies in the studies of the regulatory networks of hematopoietic precursor cell self-renewal and differentiation using the multipotent EML (erythroid, myeloid and lymphocytic) cell as a model system.